AMLX · NASDAQ · Biotechnology

Amylyx Pharmaceuticals (AMLX)

Developing avexitide-led therapies for endocrine and neurodegenerative diseases.

$33.07
vs last close+0.68 (+2.09%)

13F · 13D/G · Form 4

Institutions≈ 103.12%114.90M shares
223 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail
Insiders1.47%1.64M shares
6 holders · as of Sep 14, 2026
Strategic holders5.60%6.24M shares
1 holder · as of Feb 17, 2026
Adds to110.19%

111.42M company shares as of Sep 22, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

These groups come from separate filings that can overlap, so they add to 110.19%; nothing is left for Other.

13F · 13D/G · Form 4

HolderStakeSharesDate
FMR LLCInstitution
15.01%16.73Mas of Jun 30, 2026
BlackRock, Inc.Institution
7.92%8.83Mas of Jun 30, 2026
Perceptive Advisors LLCInstitution
7.48%8.33Mas of Jun 30, 2026
TCG Crossover Management, LLCInstitution
5.60%6.24Mas of Jun 30, 2026
TCG Crossover GP II, LLCStrategic
5.60%6.24Mfiled Feb 17, 2026
Commodore Capital LPInstitution
5.07%5.65Mas of Jun 30, 2026
Jupiter Topco LLCInstitution
4.70%5.24Mas of Jun 30, 2026
Saturn V Capital Management LLCInstitution
4.15%4.62Mas of Jun 30, 2026
Vanguard Capital Management LLCInstitution
3.79%4.22Mas of Jun 30, 2026
Morgan StanleyInstitution
2.81%3.13Mas of Jun 30, 2026
Driehaus Capital Management LLCInstitution
2.73%3.04Mas of Jun 30, 2026
First Light Asset Management, LLCInstitution
2.71%3.02Mas of Jun 30, 2026
Franklin Resources IncInstitution
2.65%2.95Mas of Jun 30, 2026
Goldman Sachs Group IncInstitution
2.57%2.86Mas of Jun 30, 2026
State Street CorpInstitution
2.34%2.60Mas of Jun 30, 2026
Geode Capital Management, LLCInstitution
2.10%2.34Mas of Jun 30, 2026
Adage Capital Partners GP, L.L.C.Institution
1.71%1.90Mas of Jun 30, 2026
JPMorgan Chase & CoInstitution
1.67%1.86Mas of Jun 30, 2026
Siren, L.L.C.Institution
1.33%1.48Mas of Jun 30, 2026
Eventide Asset Management, LLCInstitution
1.19%1.33Mas of Jun 30, 2026
683 Capital Management, LLCInstitution
1.15%1.28Mas of Jun 30, 2026
Vanguard Portfolio Management LLCInstitution
0.95%1.06Mas of Jun 30, 2026
Alyeska Investment Group, L.P.Institution
0.95%1.05Mas of Jun 30, 2026
Almitas Capital LLCInstitution
0.87%974,881as of Jun 30, 2026
Dimensional Fund Advisors LPInstitution
0.81%902,463as of Jun 30, 2026

13F, as of Jun 30, 2026

223 holders · 114.90M shares · 53 new positions · 123 increased · 62 reduced · 15 closed

HolderShares% outstandingChg q/qFiled
FMR LLC16.73M15.01%+97.4KAug 13, 2026
BlackRock, Inc.8.83M7.92%−1.8KAug 7, 2026
Perceptive Advisors LLC8.33M7.48%+50.0KAug 14, 2026
TCG Crossover Management, LLC6.24M5.60%0Aug 14, 2026
Commodore Capital LP5.65M5.07%0Aug 14, 2026
Jupiter Topco LLC5.24M4.70%+5.24MnewAug 14, 2026
Saturn V Capital Management LLC4.62M4.15%+274.2KAug 14, 2026
Vanguard Capital Management LLC4.22M3.79%+82.6KAug 13, 2026

13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
FMR LLC15.00%16.47M13GFeb 5, 2026
Perceptive Advisors LLC7.50%8.28M13GMay 15, 2026
BlackRock, Inc.7.10%7.78M13GJan 21, 2026
TCG Crossover GP II, LLC5.70%6.24M13GFeb 17, 2026
Commodore Capital LP5.10%5.65M13GNov 17, 2025

Form 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Sep 10, 2026
James M. Fratesofficer: Chief Financial Officer
Sale · 2 lots10,810$32.36233,625
Sep 10, 2026
Camille L. Bedrosianofficer: Chief Medical Officer
Sale · 2 lots10,028$32.40278,064
Sep 10, 2026
Joshua B. Cohendirector, officer: Co-Chief Executive Officer
Sale · 2 lots30,464$32.193,613,123
Sep 10, 2026
Justin B. Kleedirector, officer: Co-Chief Executive Officer
Sale · 2 lots30,464$32.183,613,056
Sep 10, 2026
Gina Mazzarielloofficer: Chief Legal Officer
Sale · 2 lots9,536$32.46190,838
Jul 10, 2026
Gina Mazzarielloofficer: Chief Legal Officer
Sale15,000$17.61179,090
Jul 9, 2026
Gina Mazzarielloofficer: Chief Legal Officer
Sale15,000$18.32194,090
May 21, 2026
Karen Firestonedirector
Purchase3,800$13.5166,900
Mar 2, 2026
Gina Mazzarielloofficer: Chief Legal Officer
Sale6,844$14.52134,430
Mar 2, 2026
James M. Fratesofficer: Chief Financial Officer
Sale7,909$14.52165,638

House and Senate disclosures

Not reported.