CYCN · NASDAQ · Biotechnology

Cyclerion Therapeutics (CYCN)

Holds a suspended depression-treatment system and out-licensed sGC development rights.

$23.52
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Cyclerion Therapeutics, Inc.CYCN
Health Care

Holds a suspended treatment-resistant-depression system and economic rights in sGC assets, earning transactional income from licensing, asset sales, and option fees rather than product sales. Operations are highly externalized, while praliciguat's progress rests with its worldwide licensee and a proposed merger remains pending.

Maintains a pre-merger portfolio centered on CYC-126, a licensed anesthetic-and-monitoring system once planned for hospital-based treatment-resistant depression, alongside economic rights in praliciguat, olinciguat licensing opportunities, and a non-controlling Tisento investment. Has no approved products or product-sale revenue, and relies on consultants and outsourced research.

Has suspended work on CYC-126 because of cash limitations while Akebia controls worldwide development and commercialization of praliciguat. A proposed all-stock reverse merger with Korsana Biosciences would shift the listed parent's primary business to Korsana if the transaction closes; current operations remain constrained by merger conditions and contractual limits on competing specified CNS-penetrant sGC programs.

Company facts

CEORegina M. Graul, Ph.D.
ListedApr 2, 2019
ExchangeNASDAQ
HeadquartersCambridge, MA
CountryUnited States
Employees1
CIK0001755237
ISINUS23255M2044

Market cap$15.7M
EPS (ttm)−$12.04
P/E (ttm)−1.95
ROE-88.0%
P/B3.09
P/S8.28
Dividend yieldDiv yield
Beta2.31vs XLV 1.47

No analyst consensus on record.

Next report
Nov 11, 26
estimated · in 49 days
EPS estimate
−$50.40
Revenue estimate
$550.0K
Fiscal quarter
Q3 FY26

EPSReportedEstimate

Mar '25May '25Aug '25Nov '25Mar '26May '26Aug '26Nov '26
Reported$0.22−$0.56−$0.11−$0.30−$1.75−$2.66−$0.41Pending
Estimate−$121.80−$2.66−$2.66−$7.10−$50.40
Surprise+99.8%+34.2%0.0%+94.2%

RevenueReportedEstimate

Mar '25May '25Aug '25Nov '25Mar '26May '26Aug '26Nov '26
Reported$1.8M$81.0K$93.0K$875.0K$1.0M$100.0KPending
Estimate$100.0K$100.0K$100.0K$1.5M$550.0K
Surprise+775.0%+925.0%0.0%
Estimate−$50.40
ReportedDue Nov 11, 2026
Estimate$550.0K
ReportedDue Nov 11, 2026
View details

Debt to equity0.00%
Current ratio82.10%

ProfitabilityRevenueNet incomeNet margin

Q3 FY24Q4 FY24Q1 FY25Q2 FY25Q3 FY25Q4 FY25Q1 FY26Q2 FY26
Revenue$194.0K$1.8M$81.0K$93.0K$875.0K$1.0M$0$0
Net income−$723.0K$530.0K−$1.4M−$324.0K−$976.0K−$799.0K−$3.2M−$1.8M
Net margin0.0%29.3%0.0%0.0%0.0%0.0%

GrowthOperating income

Q3 FY24Q4 FY24Q1 FY25Q2 FY25Q3 FY25Q4 FY25Q1 FY26Q2 FY26
Operating income−$1.1M$502.0K−$1.5M−$1.7M−$1.0M−$838.0K−$3.2M−$1.8M
YoY growthLoss narrowedTurned profitLoss narrowedLoss widenedLoss narrowedTurned lossLoss widenedLoss widened

Balance sheet, Jun 30, 2026Cash & short-term investments $1.4M · Total debt $0 · Total assets $6.9M · Shareholders' equity $5.1M

Revenue
$0
Operating income
−$1.8M
Net income
−$1.8M
View details

No dividends on record.

Institutions70.46%471.2K shares
21 holders · as of Jun 30, 2026
Insiders22.93%153.4K shares
4 holders · as of Aug 18, 2026
Other6.61%44.2K shares
remainder

668.8K company shares as of Sep 23, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

Top shareholders13F · 13D/G · Form 4

HolderStakeSharesDate
Kalehua Capital Management LLCInstitution
35.28%1.65Mas of Jun 30, 2026
Peter M. HechtInsiderdirector, 10 percent owner
19.44%130,034filed Jul 20, 2026
FMR LLCInstitution
13.88%649,547as of Jun 30, 2026
Balyasny Asset Management L.P.Institution
6.78%317,511as of Jun 30, 2026
Adar1 Capital Management, LLCInstitution
6.38%298,757as of Jun 30, 2026

Insider tradesForm 4

No open-market trades in the last 12 months.

View details

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Compare

CompanyPriceChange
Cyclerion Therapeutics$23.520.00%$15.7M8.3+23.5%
Johnson & Johnson$269.95+0.28%$648.72B31.222.76.6+6.6%
Eli Lilly$1,159.00−0.95%$1.10T39.328.313.8+47.7%
Compass Pathways (ADR)$14.18−4.07%$1.99B
Axsome Therapeutics$197.96−2.53%$10.45B1,181.113.5+44.2%
Neuronetics$2.90−0.52%$202.5M1.3+9.1%
Median35.228.310.0+26.6%