SEPN · NASDAQ · Biotechnology

Septerna (SEPN)

Develops oral GPCR drug candidates using its Native Complex Platform.

$40.38
After-hours close0.00 (0.00%)
At close$40.38(+4.77%)

13F · 13D/G · Form 4

Institutions≈ 101.18%47.23M shares
166 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail
Insiders3.09%1.44M shares
8 holders · as of Sep 3, 2026
Strategic holders13.63%6.36M shares
1 holder · as of Aug 14, 2026
Adds to117.90%

46.68M company shares as of Sep 23, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

These groups come from separate filings that can overlap, so they add to 117.90%; nothing is left for Other.

13F · 13D/G · Form 4

HolderStakeSharesDate
Ra Capital Management, L.P.Institution
14.99%7.00Mas of Jun 30, 2026
Third Rock Ventures V, L.P.1,2,3Strategic10 percent owner
13.63%6.22Mfiled Aug 14, 2026
TRV GP V, LLCInstitution
13.32%6.22Mas of Jun 30, 2026
Driehaus Capital Management LLCInstitution
9.50%4.43Mas of Jun 30, 2026
TRV GP Vi, LLCInstitution
9.02%4.21Mas of Jun 30, 2026
Samsara Biocapital, LLCInstitution
6.75%3.15Mas of Jun 30, 2026
Goldman Sachs Group IncInstitution
6.56%3.06Mas of Jun 30, 2026
BlackRock, Inc.Institution
4.14%1.93Mas of Jun 30, 2026
Siren, L.L.C.Institution
4.07%1.90Mas of Jun 30, 2026
Avoro Capital Advisors LLCInstitution
2.87%1.34Mas of Jun 30, 2026
Jupiter Topco LLCInstitution
2.80%1.31Mas of Jun 30, 2026
Vanguard Capital Management LLCInstitution
2.62%1.22Mas of Jun 30, 2026
Primecap Management Co/CA/Institution
2.50%1.17Mas of Jun 30, 2026
First Light Asset Management, LLCInstitution
2.06%963,260as of Jun 30, 2026
Adar1 Capital Management, LLCInstitution
2.02%940,747as of Jun 30, 2026
Jeffrey FinerInsiderdirector, officer: CEO and President
1.77%826,907filed Apr 4, 2025
Geode Capital Management, LLCInstitution
1.46%679,163as of Jun 30, 2026
State Street CorpInstitution
1.40%652,630as of Jun 30, 2026
Loomis Sayles & Co L PInstitution
1.34%624,752as of Jun 30, 2026
Casdin Capital, LLCInstitution
1.19%553,268as of Jun 30, 2026
Catalio Capital Management, LPInstitution
1.15%536,152as of Jun 30, 2026
Algert Global LLCInstitution
0.85%397,487as of Jun 30, 2026
Balyasny Asset Management L.P.Institution
0.75%350,442as of Jun 30, 2026
Longaeva Partners L.P.Institution
0.64%298,171as of Jun 30, 2026
Soleus Capital Management, L.P.Institution
0.59%275,000as of Jun 30, 2026
  1. Third Rock Ventures V, L.P.'s transaction reports restate only vehicles that traded; the 2025 ownership statement (6.22M) plus the 147.2K net shares acquired since is used instead.
  2. Third Rock Ventures V, L.P. reports a block also reported by TRV GP V, LLC; it is counted once, under TRV GP V, LLC.
  3. Third Rock Ventures V, L.P. reports a block also reported by Samsara Biocapital, LLC; it is counted once, under Samsara Biocapital, LLC.

13F, as of Jun 30, 2026

166 holders · 47.23M shares · 51 new positions · 102 increased · 32 reduced · 17 closed

HolderShares% outstandingChg q/qFiled
Ra Capital Management, L.P.7.00M14.99%0Aug 14, 2026
TRV GP V, LLC6.22M13.32%0Aug 10, 2026
Driehaus Capital Management LLC4.43M9.50%+37.5KAug 14, 2026
TRV GP Vi, LLC4.21M9.02%0Aug 10, 2026
Samsara Biocapital, LLC3.15M6.75%0Aug 14, 2026
Goldman Sachs Group Inc3.06M6.56%+156.3KAug 14, 2026
BlackRock, Inc.1.93M4.14%+109.9KAug 7, 2026
Siren, L.L.C.1.90M4.07%−100.0KAug 13, 2026

13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
Rajeev Shahincl. Peter Kolchinsky, RA Capital Management, L.P. +1 more15.80%7.00M13DNov 4, 2024
Third Rock Ventures V, L.P.14.00%6.22M13GMay 9, 2025
Driehaus Capital Management LLC10.46%4.66M13GJun 10, 2025
Samsara BioCapital, L.P.incl. Samsara BioCapital GP, LLC, Srinivas Akkaraju6.20%2.77M13GNov 4, 2024
BVF Partners L.P.incl. Biotechnology Value Trading Fund OS LP, BVF I GP LLC +7 more5.50%2.45M13GNov 1, 2024

Form 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Sep 1, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale3,333$37.8396,412
Aug 12, 2026
Third Rock Ventures V, L.P.10 percent owner
Sale · 2 lots147,200$50.276,068,391
Aug 12, 2026
Ra Capital Management, L.P.director, 10 percent owner:
Sale746,500$42.504,777,415
Aug 11, 2026
Elizabeth Bhattofficer: President and COO
Sale25,000$44.00174,209
Aug 3, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots3,334$34.4796,412
Jul 15, 2026
Elizabeth Bhattofficer: President and COO
Sale4,000$33.99174,209
Jul 1, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots3,333$34.3696,412
Jun 29, 2026
Samira Shaikhlyofficer: Chief People Officer
Sale2,178$35.18793
Jun 22, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots15,000$35.5196,412
Jun 12, 2026
Samira Shaikhlyofficer: Chief People Officer
Sale6,250$35.08793

House and Senate disclosures

Not reported.