Spruce Biosciences (SPRB)
Develops an enzyme therapy for Sanfilippo syndrome and a preclinical CAH antibody.
$48.63
vs last close−1.36 (−2.72%)
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13F · 13D/G · Form 4
| Institutions | 70.00% | 2.01M shares | |
|---|---|---|---|
| 65 holders · as of Jun 30, 2026 | |||
| Insiders | 1.08% | 30.9K shares | |
| 4 holders · as of Jul 9, 2026 | |||
| Strategic holders | 0.04% | 1.1K shares | |
| 1 holder · as of Oct 8, 2025 | |||
| Other | 28.88% | 830.2K shares | |
| remainder | |||
2.87M company shares as of Sep 23, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing
13F, as of Jun 30, 2026
65 holders · 2.01M shares · 37 new positions · 53 increased · 3 reduced · 4 closed
| Holder | Shares | % outstanding | Chg q/q | Filed |
|---|---|---|---|---|
| Aigh Capital Management LLC | 250.0K | 8.70% | +250.0Knew | Aug 7, 2026 |
| Orbimed Advisors LLC | 200.0K | 6.96% | +200.0Knew | Aug 14, 2026 |
| BlackRock, Inc. | 187.8K | 6.54% | +170.9K | Aug 7, 2026 |
| Millennium Management LLC | 161.0K | 5.60% | +49.1K | Aug 14, 2026 |
| Ikarian Capital, LLC | 121.4K | 4.22% | 0 | Aug 14, 2026 |
| Vanguard Capital Management LLC | 119.3K | 4.15% | +101.0K | Aug 13, 2026 |
| Alyeska Investment Group, L.P. | 81.7K | 2.84% | +30.0K | Aug 14, 2026 |
| Geode Capital Management, LLC | 70.5K | 2.45% | +57.7K | Aug 12, 2026 |
13D/G · 5% or more, as filed
| Holder | % of class | Shares | Form | Filed |
|---|---|---|---|---|
| Integrated Core Strategies (US) LLC | 9.60% | 103.0K | 13G | Feb 24, 2026 |
| Orin Hirschman | 9.10% | 250.0K | 13G | Jul 27, 2026 |
| BlackRock, Inc. | 6.80% | 187.8K | 13G | Jul 30, 2026 |
| Boone Peter David Mr | 6.40% | 68.2K | 13G | Nov 24, 2025 |
| ADAR1 Capital Management, LLC | 5.40% | 58.0K | 13G | Feb 17, 2026 |
| AWM Investment Company, Inc. | 5.10% | 147.0K | 13G | Aug 14, 2026 |
| Citadel Advisors LLC | 5.10% | 70.0K | 13G | May 15, 2026 |
Form 4
Latest trades
| Date | Insider | Type | Shares | Avg price | Owned after |
|---|---|---|---|---|---|
| Oct 6, 2025 | Parkman Healthcare Partners LLC10 percent owner | Sale · 2 lots | 257 | $19.14 | 1,050 |
| Oct 6, 2025 | Parkman Healthcare Partners LLC10 percent owner | Purchase | 256 | $17.91 | 1,307 |
House and Senate disclosures
Not reported.