TSHA · NASDAQ · Biotechnology

Taysha Gene Therapies (TSHA)

Advances TSHA-102, an AAV9 gene therapy in pivotal testing for Rett syndrome.

$5.28
After-hours close+0.13 (+2.45%)
At close$5.16(+2.28%)

13F · 13D/G · Form 4

Institutions≈ 92.12%300.17M shares
216 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail
Insiders9.63%31.38M shares
7 holders · as of Jul 10, 2026
Adds to101.75%

325.83M company shares as of Sep 23, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

These groups come from separate filings that can overlap, so they add to 101.75%; nothing is left for Other.

13F · 13D/G · Form 4

HolderStakeSharesDate
Paul B. Manning1Insider10 percent owner
7.86%25.60Mfiled Jun 3, 2025
Avoro Capital Advisors LLCInstitution
7.33%23.89Mas of Jun 30, 2026
Ra Capital Management, L.P.Institution
7.23%23.56Mas of Jun 30, 2026
Goldman Sachs Group IncInstitution
6.97%22.71Mas of Jun 30, 2026
BlackRock, Inc.Institution
6.35%20.69Mas of Jun 30, 2026
Vestal Point Capital, LPInstitution
5.96%19.42Mas of Jun 30, 2026
Morgan StanleyInstitution
5.06%16.49Mas of Jun 30, 2026
RTW Investments, LPInstitution
4.16%13.56Mas of Jun 30, 2026
FMR LLCInstitution
4.09%13.34Mas of Jun 30, 2026
Vanguard Capital Management LLCInstitution
3.83%12.48Mas of Jun 30, 2026
State Street CorpInstitution
3.51%11.42Mas of Jun 30, 2026
Siren, L.L.C.Institution
3.02%9.85Mas of Jun 30, 2026
Octagon Capital Advisors LPInstitution
2.97%9.69Mas of Jun 30, 2026
Geode Capital Management, LLCInstitution
2.01%6.56Mas of Jun 30, 2026
Polar Capital Holdings PLCInstitution
1.57%5.12Mas of Jun 30, 2026
Bioimpact Capital LLCInstitution
1.38%4.50Mas of Jun 30, 2026
D. E. Shaw & Co., Inc.Institution
1.35%4.40Mas of Jun 30, 2026
Baker Bros. Advisors LPInstitution
1.23%4.00Mas of Jun 30, 2026
Wellington Management Group LLPInstitution
1.22%3.98Mas of Jun 30, 2026
Healthcare of Ontario Pension Plan Trust FundInstitution
1.19%3.89Mas of Jun 30, 2026
Casdin Capital, LLCInstitution
1.00%3.25Mas of Jun 30, 2026
Vanguard Portfolio Management LLCInstitution
0.96%3.14Mas of Jun 30, 2026
Adar1 Capital Management, LLCInstitution
0.93%3.04Mas of Jun 30, 2026
Sean P. NolanInsiderdirector, officer: Chief Executive Officer
0.89%2.91Mfiled Jan 27, 2026
Pictet Asset Management Holding SAInstitution
0.85%2.77Mas of Jun 30, 2026
  1. Paul B. Manning's transaction reports restate only vehicles that traded; the 2025 ownership statement (25.60M) is used instead.

13F, as of Jun 30, 2026

216 holders · 300.17M shares · 45 new positions · 143 increased · 41 reduced · 25 closed

HolderShares% outstandingChg q/qFiled
Avoro Capital Advisors LLC23.89M7.33%+2.19MAug 14, 2026
Ra Capital Management, L.P.23.56M7.23%0Aug 14, 2026
Goldman Sachs Group Inc22.71M6.97%+343.5KAug 14, 2026
BlackRock, Inc.20.69M6.35%+2.33MAug 7, 2026
Vestal Point Capital, LP19.42M5.96%+1.42MAug 14, 2026
Morgan Stanley16.49M5.06%−1.48MAug 13, 2026
RTW Investments, LP13.56M4.16%−120.0KAug 14, 2026
FMR LLC13.34M4.09%−984.8KAug 13, 2026

13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
Avoro Capital Advisors LLCincl. Behzad Aghazadeh9.99%23.09M13GNov 14, 2024
RA Capital Management, L.P.9.90%27.66M13GNov 14, 2025
Paul B Manningincl. The Paul B. Manning Revocable Trust dated May 10, 2000, The PBM 2023 Grantor Retained Annuity Trust +3 more9.80%25.60M13DJun 3, 2025
RTW Investments, LP7.00%20.69M13GMay 15, 2026
Morgan Stanley6.70%16.86M13GAug 6, 2025
BlackRock, Inc.6.50%17.85M13GJan 21, 2026
Vestal Point Capital, LP6.30%18.00M13GMay 15, 2026
The Goldman Sachs Group, Inc.5.10%12.75M13GJul 3, 2025

Form 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Jul 10, 2026
Sukumar Nagendrandirector, officer: President and Head of R&D
Sale200,000$6.24936,410
Apr 10, 2026
Sukumar Nagendrandirector, officer: President and Head of R&D
Sale200,000$4.461,136,410
Feb 4, 2026
Kamran Alamofficer: CHIEF FINANCIAL OFFICER
Sale1,655$4.521,442,131
Jan 26, 2026
Kamran Alamofficer: CHIEF FINANCIAL OFFICER
Sale23,849$4.611,443,786
Jan 23, 2026
Kamran Alamofficer: CHIEF FINANCIAL OFFICER
Sale78,968$4.751,467,635
Jan 26, 2026
Sean P. Nolandirector, officer: Chief Executive Officer
Sale41,312$4.612,908,257
Jan 23, 2026
Sean P. Nolandirector, officer: Chief Executive Officer
Sale136,789$4.752,949,569
Jan 26, 2026
Sukumar Nagendrandirector, officer: President and Head of R&D
Sale26,918$4.611,317,389
Jan 23, 2026
Sukumar Nagendrandirector, officer: President and Head of R&D
Sale89,132$4.751,344,307
Jan 12, 2026
Sukumar Nagendrandirector, officer: President and Head of R&D
Sale200,000$4.711,006,439

House and Senate disclosures

Not reported.