TYRA · NASDAQ · Biotechnology

Tyra Biosciences (TYRA)

Developer of oral FGFR-targeted medicines for urothelial cancers and achondroplasia.

$25.38
vs last close−0.27 (−1.05%)

13F · 13D/G · Form 4

Institutions≈ 115.93%69.18M shares
177 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail
Insiders2.86%1.71M shares
9 holders · as of Sep 17, 2026
Strategic holders29.64%17.69M shares
3 holders · as of May 15, 2026
Adds to148.43%

59.68M company shares as of Sep 22, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

These groups come from separate filings that can overlap, so they add to 148.43%; nothing is left for Other.

13F · 13D/G · Form 4

HolderStakeSharesDate
Ra Capital Management, L.P.Institution
20.44%12.20Mas of Jun 30, 2026
Boxer Capital Management, LLCStrategicother: See remarks.
18.26%10.90Mfiled Oct 22, 2024
FMR LLCInstitution
14.95%8.92Mas of Jun 30, 2026
Jupiter Topco LLCInstitution
7.29%4.35Mas of Jun 30, 2026
Janus Henderson Group PLCStrategic
6.52%3.89Mfiled May 15, 2026
Alta Partners Management Company, L.P.Institution
6.41%3.82Mas of Jun 30, 2026
Nextech Invest, Ltd.Institution
5.95%3.55Mas of Jun 30, 2026
TCG Crossover Management, LLCInstitution
5.44%3.25Mas of Jun 30, 2026
BlackRock, Inc.Institution
5.08%3.03Mas of Jun 30, 2026
TCG Crossover GP I, LLCStrategic
4.86%2.90Mfiled Mar 6, 2025
Price T Rowe Associates Inc /MD/Institution
4.66%2.78Mas of Jun 30, 2026
State Street CorpInstitution
3.59%2.14Mas of Jun 30, 2026
Commodore Capital LPInstitution
3.14%1.88Mas of Jun 30, 2026
Paradigm Biocapital Advisors LPInstitution
3.06%1.83Mas of Jun 30, 2026
Vanguard Capital Management LLCInstitution
2.53%1.51Mas of Jun 30, 2026
BVF Inc/ILInstitution
2.47%1.48Mas of Jun 30, 2026
Todd Harris1Insiderdirector, officer: President and CEO
2.41%1.44Mfiled Sep 17, 2026
5Am Venture Management, LLCInstitution
1.72%1.03Mas of Jun 30, 2026
Deerfield Management Company, L.P. (Series C)Institution
1.70%1.02Mas of Jun 30, 2026
Hood River Capital Management LLCInstitution
1.70%1.02Mas of Jun 30, 2026
Geode Capital Management, LLCInstitution
1.63%970,734as of Jun 30, 2026
Caligan Partners LPInstitution
1.35%806,986as of Jun 30, 2026
Canaan Partners Xi LLCInstitution
1.26%750,000as of Jun 30, 2026
Siren, L.L.C.Institution
1.21%725,000as of Jun 30, 2026
Sio Capital Management, LLCInstitution
1.17%695,315as of Jun 30, 2026
  1. Reported at 4.80% on May 14, 2026, under the 5% line, so no further filing is required.

13F, as of Jun 30, 2026

177 holders · 69.18M shares · 36 new positions · 110 increased · 44 reduced · 25 closed

HolderShares% outstandingChg q/qFiled
Ra Capital Management, L.P.12.20M20.44%0Aug 14, 2026
FMR LLC8.92M14.95%+1.17MAug 13, 2026
Jupiter Topco LLC4.35M7.29%+4.35MnewAug 14, 2026
Alta Partners Management Company, L.P.3.82M6.41%0Jul 22, 2026
Nextech Invest, Ltd.3.55M5.95%−502.3KAug 14, 2026
TCG Crossover Management, LLC3.25M5.44%0Aug 14, 2026
BlackRock, Inc.3.03M5.08%+814.0KAug 7, 2026
Price T Rowe Associates Inc /MD/2.78M4.66%+1.80MAug 14, 2026

13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
Peter Kolchinskyincl. Rajeev Shah, RA Capital Healthcare Fund, L.P. +1 more19.90%14.13M13DSep 17, 2026
FMR LLC14.40%7.75M13GApr 7, 2026
Janus Henderson Group PLC7.20%3.89M13GMay 15, 2026
Paradigm BioCapital Advisors LP5.80%3.47M13GSep 17, 2026
TCG Crossover GP I, LLC5.70%2.90M13GMar 6, 2025
Commodore Capital LP5.20%2.75M13GMay 14, 2025
BlackRock, Inc.5.00%2.98M13GJul 30, 2026

Form 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Sep 15, 2026
Ra Capital Management, L.P.director, 10 percent owner:
Purchase9,078,529$0.001011,616,986
Sep 9, 2026
Rehan Verjeedirector
Purchase972$20.58972
Mar 25, 2026
Gilla Kaplandirector
Sale14,295$36.9728,231
Feb 12, 2026
Daniel Bensenofficer: Chief Discovery Officer
Sale · 2 lots8,000$32.87146,981
Jan 12, 2026
Daniel Bensenofficer: Chief Discovery Officer
Sale · 2 lots8,000$28.52154,981
Dec 19, 2025
Robert J. Moredirector
Sale10,000$25.003,823,425
Dec 12, 2025
Daniel Bensenofficer: Chief Discovery Officer
Sale8,000$22.64162,981
Nov 21, 2025
Robert J. Moredirector
Sale246,871$20.253,833,425
Nov 19, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale49,956$16.32170,981
Nov 18, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale75,633$16.07220,937

House and Senate disclosures

Not reported.