Personalis (PSNL)
Whole-genome liquid biopsy tests that track cancer recurrence at the molecular level.
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Develops and operates whole-genome, tumor-informed liquid biopsy tests for molecular residual disease detection in cancer patients, commercialized through partnerships with Tempus AI and other oncology networks. Revenue is concentrated in the US and tied to Medicare reimbursement coverage and volume from a small number of enterprise sequencing partners.
Runs a CLIA-certified, CAP-accredited genomics laboratory in Fremont, California that processes tumor and blood samples for cancer centers, biopharma partners, and a population-sequencing program for the U.S. Department of Veterans Affairs.
The flagship product is NeXT Personal®, a whole-genome, tumor-informed liquid biopsy assay that detects ultra-low levels of molecular residual disease, using up to roughly 1,800 patient-specific somatic variants from an initial tumor sample.
Clinical reach runs through Tempus AI in lung, breast, and immunotherapy monitoring; Natera draws on a separate exome-sequencing supply agreement for its Signatera test; Moderna uses ImmunoID NeXT to underpin an individualized neoantigen therapy program.
Revenue depends on Medicare reimbursement decisions — which expanded across breast and lung cancer surveillance through 2025–2026 — and on volume from a small number of enterprise partners.
Company facts
Target rangeAs of Sep 21, 2026
Latest analyst notes
| Date | Firm | Action | Prior | Current |
|---|---|---|---|---|
| Aug 24, 2026 | Craig-Hallum | Downgrade | Rating: —Target: — | Target: $16.25 |
| Jul 21, 2026 | BTIG | Reiterate | Rating: —Target: $11 | Target: $16.25 |
| Jul 20, 2026 | Needham | Downgrade | ||
| Jul 20, 2026 | Lake Street | Downgrade | Target: $11 | Target: $16.25 |
| Jul 17, 2026 | Needham | Reiterate | Rating: —Target: $10 | Target: $17 |
EPSReportedEstimate
RevenueReportedEstimate
Balance sheet, Jun 30, 2026Cash & short-term investments $212.7M · Total debt $38.0M · Total assets $312.1M · Shareholders' equity $235.2M
- Revenue
- $22.4M
- Operating income
- −$33.6M
- Net income
- −$31.7M
No dividends on record.
| Institutions | ≈ 79.05% | 84.43M shares | |
|---|---|---|---|
| 169 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail | |||
| Insiders | 0.79% | 843.6K shares | |
| 10 holders · as of Jul 15, 2026 | |||
| Strategic holders | 12.21% | 13.04M shares | |
| 1 holder · as of Jul 21, 2026 | |||
| Other | ≈ 7.95% | 8.49M shares | |
| remainder | |||
106.80M company shares as of Sep 22, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing
This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.
Top shareholders13F · 13D/G · Form 4
| Holder | Stake | Shares | Date |
|---|---|---|---|
Merck & Co., Inc.Institution | 13.15% | 14.04M | as of Jun 30, 2026 |
Tempus AI, Inc.Strategic10 percent owner | 12.21% | 13.04M | filed Jul 21, 2026 |
Ark Investment Management LLCInstitution | 7.74% | 8.27M | as of Jun 30, 2026 |
BlackRock, Inc.Institution | 6.63% | 7.08M | as of Jun 30, 2026 |
Lightspeed Management Company, L.L.C.Institution | 5.71% | 6.10M | as of Jun 30, 2026 |
Insider tradesForm 4
| Date | Insider | Role | Shares | Avg price |
|---|---|---|---|---|
| Jul 15, 2026 | Richard Chen | officer: President and CMO | −100,000 | $15.15 |
| Jul 9, 2026 | Christopher M. Hall | director, officer: Chief Executive Officer | −100,000 | $15.08 |
| Jun 29, 2026 | Aaron Tachibana | officer: CFO AND COO | −4,982 | $14.00 |
| Jun 26, 2026 | Christopher M. Hall | director, officer: Chief Executive Officer | −100,000 | $13.15 |
| Jun 26, 2026 | Aaron Tachibana | officer: CFO AND COO | −51,251 | $13.18 |
- Natera
Head-to-head in tumor-informed MRD via Signatera, the category leader.
- Guardant Health
Competes in MRD with Guardant Reveal and in CGP with Guardant360.
- Myriad Genetics
Precise MRD is the closest WGS tumor-informed analog to NeXT Personal.
- Tempus AI
Partner-competitor: distributes NeXT Personal Dx but rivals in CGP and data.
- Veracyte
TrueMRD WGS-based MRD launching 2026 brings new head-to-head competition.
- NeoGenomics
RaDaR ST tumor-informed MRD plus broad oncology CGP services overlap.
- Caris Life Sciences
Caris MI Profile competes with NeXT Dx for comprehensive tumor profiling.
Compare
| Company | Price | Change | |||||
|---|---|---|---|---|---|---|---|
| Personalis | $16.40 | +0.97% | $1.73B | — | — | 24.9 | +30.0% |
| Natera | $389.33 | +5.04% | $53.08B | — | — | 19.6 | +37.7% |
| Guardant Health | $177.36 | +2.01% | $23.33B | — | — | 19.7 | +44.3% |
| Myriad Genetics | $3.95 | −1.38% | $378.7M | — | — | 0.5 | −10.5% |
| Tempus AI | $77.97 | −0.08% | $13.67B | — | — | 9.5 | +21.6% |
| Veracyte | $43.28 | +4.23% | $3.31B | 29.7 | 23.8 | 5.9 | +15.5% |
| NeoGenomics | $19.13 | −1.46% | $498.7M | — | 68.8 | 0.7 | +11.2% |
| Caris Life Sciences | $31.78 | +3.69% | $8.66B | 85.6 | 126.2 | 8.8 | +45.4% |
| Median | 57.6 | 68.8 | 8.8 | +21.6% |